Bio-Modeling Systems: The Mechanisms-Based Mecidicine Company
  • 2019: ANNOUNCEMENT: Paris November 28, 2019: Bio-Modeling Systems invited to the PolePharma event "Industrie du futur" to present its collaboration with L2F the EPFL AI company adding a third dimension to AI through the Giotto program.
  • 2019: PRESS RELEASE: Paris November 6, 2019: Bio-Modeling Systems updates its pipeline of therapies, diagnostics, and bioprocesses and invites you to meet its team at BioFit and Polepharma Bio-Production conferences.
  • 2019: ANNOUNCEMENT: Lyon October 17-18, 2019: Bio-Modeling Systems invited at the India-France Knowledge Summit 2 to contribute with its CADI Discovery Platform, the other AI, successfully applied to its Indo-French   therapeutic program UMANG (now Arbuza Regenerate company) addressing  a public health issue concerning 50-100 millions children in India.
  • 2019: PRESS RELEASE: Paris October 1, 2019: Bio-Modeling Systems, the Mechanisms-Based Cosmetics company, is invited to present its CADI™ Discovery platform and 7 outputs at the open Innovation sessions of Cosmetic-360

  • 2019: ANNOUNCEMENT: Lille Juily 2-4, 2019: BMSystems invited as speaker at ANTIMIC 2019: Bacteriophages, Genius and success of precision medicine in infections (ATC HCl) and new tracks for microbiote “surgery” controt with GEMMA microbiota &Autism H2O2O program
  • 2019: PRESS-RELEASE: Paris May 30, 2019 : Manuel GEA, CEO of BMSystems, joins Bolero's Pharma/Health Advisory Board to strengthen their services and accelerate the convergence between clinical research and Real Life Data

  • 2019: ANNOUNCEMENT: Paris May 5, 2019: Bio-Modeling Systems is participating to Neurodegenerative Drug Development Europe Conference in Paris (May 22-23, 2019). Meet us to discover our Alzheimer's and Parkinson’s diseases solutions.
  • 2019: ANNOUNCEMENT: BMSystems will be participating to  Polepharma microbiota conference (the N°1 pharmaceutical cluster in Europe) event to present its GEMMA microbiota &Autism H2O2O program !
  • 2019: PRESS-RELEASE: Paris April  2, 2019: Bio-Modeling Systems, the 14 M€ H2020 GEMMA (Autism and Microbiota) integrative biology partner, announces the release of the public program web site: for the World Autism Awareness Day.
  • 2019-NEW-YEAR PROGRAM: Paris January 24, 2019: In 2019, our founding motto: “Understand disease mechanisms first. Adapted treatments will follow.” is still highly relevant. FRENCH

  • 2018: POSITION PAPER : Paris December 2, 2018: SMART STRATEGY vs. BIG STRATEGY: How Augmented Intelligence, the other AI, addresses the digital “garbage in garbage out” reality and the life complexity

  • 2018: ANNOUNCEMENT: BMSystems invited to present its CADI Discovery platform and achievements at 4 events in Europe,BioFit,-BioWin-Day,COST EC cluster conference, DGA BtoB  

Bio-Modeling Systems: The Mechanisms-Based Mecidicine Companys

CADI™ (Computer Augmented Deductive Intelligence) Discovery - Value Proposition

BMSystems' team builds heuristic non-mathematical CADI™ models to generate novel disruptive concepts from scientific, medical & health data.

BMSystems' answers to clients / partners' needs:

With CADI™ Discovery, BMSystems possesses a truly unique competitive advantage: the ability to address and exploit the two major issues in life sciences

  1. the enormous complexity of life’s mechanisms, and
  2. the significant and growing unreliability of scientific and clinical publications.

Through its dual contractual & collaborative business model, BMSystems:

  1. proposes robust R&D and Business decision-making support, and
  2. discovers cost-effective, lower risk, patentable novel integrated solutions, for medicine, health technologies, nutrition and cosmetics.

You have a question; we may have the ability to generate the answer through one of our 6 BMSystems’ solutions to critical & high impact issues.

  1. GO-NO GO decision before product acquisition or for portfolio risk analysis.
  2. GO-NO GO decision before next development phase.
  3. R&D program Rescue for a program facing critical issues during its lifetime.
  4. External R&D “B plan” program when the “A plan” cannot be rescued.
  5. Exploratory Discovery program to discover novel causal mechanisms concepts.
  6. Novel Hypotheses for therapeutic and/or diagnostic solutions discovery.

BMSystems generates solutions better, faster, cheaper and safer:

  • Physiological / Diseases Mechanisms understanding
    • Multi-Systems mechanisms
    • Multi-Scale mechanisms description
  • Targets discovery & validation.
  • Signatures of biomarkers discovery & validation.
  • Marketing strategies rational support
  • Adaptive clinical trials rational support
  • Market Access rational support
  • New therapeutic / diagnostic / cosmetics strategies,
    • New associations of molecules & devices
    • New associations of existing molecules
    • Molecules / Devices Mechanisms of action
  •  R&D / Molecules / clinical programs evaluation:
    • Next Phase GO / NO GO decision
    • Novel Clinical phases end points / processes
    • Drug (re) positioning /(re) profiling
    • Rare diseases drugs repositioning
    • Drug side effects analysis for rescue
    • Chemical entities safety issues (Allergy, PE, etc…)

BMSystems' markets: All applications linked to life sciences

  • Pharma, diagnostic, cosmetics: Red/biomedical Biotech.
  • Chemistry: White/Industrial biotech.
  • Environment: Yellow/environmental Biotech.
  • Energy:  Renewable Energy Biotech.

CADI™ Discovery Competitive advantages: Running life sciences R&D programs better, faster, cheaper and safer

  • Better-Faster: The CADI™ (Computer Assisted Deductive Integration) proprietary modeling approach invented in 2002 by Dr. François Iris,  is the first successful operational application of the "negative selection concept" in life sciences. This disruptive innovation in the field of systems biology places back the biologists in the center of the game, computational science providing the necessary tools to help them work better and faster.
  • Better: The CADI™ process, has proven since 2003 (first publication in history of a biologically validated model of a complex human disease) to be the most efficient synergic process combining organic non-linear integration (Brain intelligence ) and in-silico data processing power (collecting, structuring and manipulating data) to build validated biological interaction maps that describe biological reality better.
  • Better and safer: The CADI™ model can describe the dynamics of a pathological process and/or a pathological status vs. control and allows to switch from "symptomatic" to "causal" medicine. Because we work on mechanisms associated with specific pathways it becomes easier to predict and identify pertinent biomarkers and to propose new therapeutic strategies. At every steps of the preclinical and clinical development program, it is easy to go back to the model and rework it if necessary, making drug development better and safer.
  • Faster and cheaper: The CADI™ models belong to the non-mathematical holistic and heuristic class of models. Because we do not need to describe the complete system, the development of a CADI™ model leads to directly exploitable results, when the majority of our competitors are still trying to build operational systems. CADI™ is faster and cheaper.
  • Faster and cheaper: The CADI™ models are surely not exact maps of the complex reality, but they are pertinent representations that gather the minimum knowledge and intelligence necessary to describe a living process in a defined context and allows researchers to take the best possible decisions for the best possible results. They can be the most efficient necessary step to define the contexts and the parameters needed to build, local pertinent mathematical models for faster and cheaper optimization.
  • Better, faster and cheaper: The CADI™ process re-invented and made highly productive the synergic collaboration between experimental and integrative biology, implementing the unique CADI™ 4 steps validation process. Because a CADI™ model explains what, where, when to validate, it becomes possible to invent simple but highly pertinent & cost effective experimentations to get Yes/No answers better, faster and cheaper.
Bio-Modeling Systems: a leading Integrative Heuristic Systems Biology / Predictive Integrative Biology Mechanisms-Based Medicine company that delivers