Bio-Modeling Systems: The Mechanisms-Based Mecidicine Company: Theranexus & Pherecydes-Pharma POCs
Bio-Modeling Systems: a leading Integrative Heuristic Systems Biology / Predictive Integrative Biology company that delivers

BMSystems history

1989 -1993 Dr. Iris is Group Leader at the CEPH in Paris

  • The CEPH is a Research Institute founded and lead by Nobel laureate Prof. Jean Dausset.
  • Develops methods for high-throughput (HT) sequencing & data integration.
  • Realizes that the links between genome & biological processes are non-linear.
  • One gene = several proteins = multiple interactions = many context-dependent functions.

1993 -1996 Dr. Iris creates & leads Millennium Pharmaceuticals' (USA) HT Sequencing Unit

  • He undertakes the first attempts to carry-out physiological modeling via large scale data integration.
  • He invents & develops the basic tools and methods required for Integrative Biology.
  • Successful completion of two models, leading to the discovery of the UCP2 and EST1 genes and their roles in obesity and hyperglycemia.
  • He realizes that since published information is:
    • incomplete (to an unknown extent),
    • slanted (to an unknown extent),and often
    • incorrect (to an unknown extent).
  • Methodologies to access/generate complementary unbiased information are required

1996-2001 - Dr. Iris is co-founder and C.S.O. of ValiGen SA in Paris

  • He invents, develops and patents 4 new differential gene-expression and genotyping technologies.
  • He invents and develops the computerized data gathering, data mining, clustering and integration tools & technologies necessary for the industrial development of  Integrative Biology / Systems Biology (European "Eureka" grant: 18.6 M Euros).
  • He finalizes the Bio-Graph™ analytical platform based on the "positive selection" concept.
  • He develops the Tamoxifen Resistance model with Bio-Graph™.
  • He identifies the limitations of this analytical platform.

1999-2001 - Dr. Iris meets Mr. M.Gea and Dr. G.Dine

  • Dr. Iris meets M.Gea and Prof. G.Dine, founding members of Centrale-Santé.
  • Dr. François Iris becomes a member of Centrale-Santé's Directorate, the Healthcare & Biotech Think Tank of the Centrale's alumni's Association.
  • He decides to abandon the Bio-Graph™  platform and starts working on a second Generation analytical platform (CADI™) based on the negative selection concept.
  • He starts to work on the first version of the Creutzfeldt-Jakob Disease model. 

2002-2003 -  Dr. Iris, M. Gea and Dr. Dine initiate the BMSystems project

  • Conception of the first European private biotech company specialized in Predictive Integrative biology / Systems Biology.
  • Paul-Henri Lampe, and Pablo Santamaria, members of Centrale-Santé Think Tank, decide to join the project.
  • Development of the CADI™ analytical platform.
  • Four new models completed (FGF4-driven fibroblast differentiation, hypercholesterolemia, Chronic Fatigue Syndrome, Creutzfeldt Jakob disease) two of which are undergoing independent biological evaluation.

2004 - The company is created and starts business operations

Created in 2004, profitable since 2006, thanks to our recurrent clients, our patented collaborative discoveries already led to:

  1. A world's first in neurodegenerative diseases (publication) with CEA: 2 awards in the US & Europe

  2. Pherecydes-Pharma: BMSystems' spin-off, MR infections therapies,  publication, world's first clinical trial with phages in Phase I/II,

  3. Theranexus: CEA Life Sciences' spin-off exploiting  CEA/BMSystems' copatent  WO/2010/029131, in CNS therapies, successful Phase I,  Phase II entry.  

 

Bio-Modeling Systems: a leading Integrative Heuristic Systems Biology / Predictive Integrative Biology company that delivers ?>