Bio-Modeling Systems: The Mechanisms-Based Mecidicine Company
  •  2019: PRESS RELEASE: Paris November 6, 2019: Bio-Modeling Systems updates its pipeline of therapies, diagnostics, and bioprocesses and invites you to meet its team at BioFit and Polepharma Bio-Production conferences.
       
  • 2019: ANNOUNCEMENT: Lyon October 17-18, 2019: Bio-Modeling Systems invited at the India-France Knowledge Summit 2 to contribute with its CADI Discovery Platform, the other AI, successfully applied to its Indo-French   therapeutic program UMANG (now Arbuza Regenerate company) addressing  a public health issue concerning 50-100 millions children in India.
     
  • 2019: PRESS RELEASE: Paris October 1, 2019: Bio-Modeling Systems, the Mechanisms-Based Cosmetics company, is invited to present its CADI™ Discovery platform and 7 outputs at the open Innovation sessions of Cosmetic-360

  • 2019: ANNOUNCEMENT: Lille Juily 2-4, 2019: BMSystems invited as speaker at ANTIMIC 2019: Bacteriophages, Genius and success of precision medicine in infections (ATC HCl) and new tracks for microbiote “surgery” controt with GEMMA microbiota &Autism H2O2O program
      
  • 2019: PRESS-RELEASE: Paris May 30, 2019 : Manuel GEA, CEO of BMSystems, joins Bolero's Pharma/Health Advisory Board to strengthen their services and accelerate the convergence between clinical research and Real Life Data

  • 2019: ANNOUNCEMENT: Paris May 5, 2019: Bio-Modeling Systems is participating to Neurodegenerative Drug Development Europe Conference in Paris (May 22-23, 2019). Meet us to discover our Alzheimer's and Parkinson’s diseases solutions.
      
  • 2019: ANNOUNCEMENT: BMSystems will be participating to  Polepharma microbiota conference (the N°1 pharmaceutical cluster in Europe) event to present its GEMMA microbiota &Autism H2O2O program !
      
  • 2019: PRESS-RELEASE: Paris April  2, 2019: Bio-Modeling Systems, the 14 M€ H2020 GEMMA (Autism and Microbiota) integrative biology partner, announces the release of the public program web site: www.gemma-project.eu for the World Autism Awareness Day.
     
  • 2019-NEW-YEAR PROGRAM: Paris January 24, 2019: In 2019, our founding motto: “Understand disease mechanisms first. Adapted treatments will follow.” is still highly relevant. FRENCH

  • 2018: POSITION PAPER : Paris December 2, 2018: SMART STRATEGY vs. BIG STRATEGY: How Augmented Intelligence, the other AI, addresses the digital “garbage in garbage out” reality and the life complexity

  • 2018: ANNOUNCEMENT: BMSystems invited to present its CADI Discovery platform and achievements at 4 events in Europe,BioFit,-BioWin-Day,COST EC cluster conference, DGA BtoB  

Bio-Modeling Systems: The Mechanisms-Based Mecidicine Companys

CADI™ (Computer Augmented Deductive Intelligence) Discovery - Publications

CADI™ Models publications in prestigious international peer-reviewed journals

  • 2018: Current Opinion in Pharmacology:  How scientific literature analysis yields innovative therapeutic hypothesis through integrative iteration.
  • 2014:CNS Psychiatry publication: American Journal of Psychiatry and Neuroscience. Second publications with Max Planck  Institute of Psychiatry in Munich: Differential proteomics analyses reveal anxiety-associated molecular and cellular mechanisms in cingulate cortex. The first output of the DECIUS CNS research program. synapses.
  • 2012: CNS Neurodegenerative & Psychiatry publication: PharmacoPsychiatry publishes the first review describing a productive vision of Systems Medicine that will change R&D organization and interactions between clinicians & researchers & reveals how the world's first explanation of the mechanisms of the Creutzfeldt-Jakob disease led to the discovery of a  new therapeutic strategies for psychiatric disorders! Clearly, the brain cannot be reduced to its neurons only!
  • 2011: CNS PSYCHIATRY: Pharmaco Psychiatry publication: Fith publication with The max Planck Institute of Psychiatry in Munich: Proteome-Based Pathway Modelling of Psychiatric Disorders that describes a new analytical paradigm to definitively move research from plethoric statistical biomarkers.
  • 2010: INFECTIOUS DISEASES: Biosecurity and Bioterrorism: Biodefense Strategy, Practice, and Science Fourth publication with Pherecydes-Pharma :Genetically Engineered Virulent Phage Banks in the Detection and Control of Emergent Pathogenic Bacteria.
  • 2009. TISSUE DIFFERENTIATION : Medecine & Sciences (French) : Third CADI model validated. Mullerian regression explanation. Modelisation integrative predictive et biologie experimentale. Un processus synergique remarquablement efficace au service de la recherche medicale
  • 2005, CANCER: Journal of molecular Endocrinology: Integrative analysis of gene expression patterns predicts specific modulations of defined cell functions by estrogen and Tamoxifen in MCF7 breast cancer cells. Publication in collaboration with the INSERM unit 553.
  • 2003, CANCER: Nucleic Acids Research: Integrated transcriptome analysis of the cellular mechanisms associated with Ha-ras-dependent malignant transformation of the human breast epithelial MCF7 cell line Publication in collaboration with the INSERM unit 553. World first. First in-silico model of a complex human disease validated in-vitro and published.

Collaboration to Scientific reference books and reports

  • 2015: Publication: Cosmetics skincare: Alternative to Animal Testing : Harnessing system-level modeling to effectively alleviate the needs for animal testing.Cosmetics
  • 2014, Cosmetics skincare: Computational Biophysics of the Skin reference book. Contribution to chapter: Heuristic Modeling Applied to Epidermal Homeostasis; François Iris, Manuel Gea, Paul-Henri Lampe, and Bernard Querleux
  • 2014, European Commission: consortium CASyM:  BMSystems selected in the Europe-wide inventory of industry involve in Systems Medicine of The Coordinating Action Systems Medicine (CASyM) funded by the FP 7. The objective was to identify areas of successful innovation and exploitation.The CASyM is a multidisciplinary European consortium that joined forces to develop an implementation strategy (road map) for Systems Medicine.
  • 2010, The European Commission "From Systems Biology to Systems Medicine" report: BMSystems' heuristic systems biology research contribution to the report. The world's first explanation of the mechanisms of the Creutzfeldt-Jakob disease led to the discovery of a truly innovative psychiatric treatment recognized as one of the three best world's practice in systems medicine
  • 2008, CNS: Biomarkers for Psychiatric Disorders. (Ref. ISBN: 978-0-387-79250-7, November 2008). Dr. Francois Iris, author of the integrative biology chapter of the Book. The editor, Christoph W. Turck, is head of the Proteomics and Biomarkers branch at the Max Planck Institute of Psychiatry and holds faculty appointments in the Department of Biochemistry at Ludwig Maximilians University Munich and the International Max Planck Research School for Molecular and Cellular Life Sciences
  • 2008, CNS: Integrative Biology in the discovery of relevant biomarkers monitoring cognitive disorders pathogenesis and progression. BioTribune Springer publisher Vol. 28, august 2008.
  • 2005, Systems Biology: Computer-Assisted Integration into Biological Pathways of Modulated Gene Expressions Patterns. In «  Bioinformatics: New Research  », Yan PV editor, Chapter IV, pp 81-100 Nova Publishers (ISBN: 1-59454-242-2 2005)
Bio-Modeling Systems: a leading Integrative Heuristic Systems Biology / Predictive Integrative Biology Mechanisms-Based Medicine company that delivers